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Study, year Poewe et al. 1986 Hely et al. 1994 Montastruc et al. 1994 Dupont et al. 1996 DATATOP 1996 Koller et al. 1999 Rascol et al. 2000 PSG 2000 Rajput et al. 2002 Prevalence of complication 52 % wearing off 54% dyskinesia 41% wearing off 34% wearing off 48% dyskinesia 59% fluctuations 41% dyskinesia 50% wearing off 30% dyskinesia 20% wearing off 20% dyskinesia 45% dyskinesia 30% dyskinesia 15% dyskinesia 31% dyskinesia Length of study years ; 6 5 Method of evaluation Webster scale Modified Columbia Scale Modified Columbia Scale Physician evaluation Columbia Scale, UPDRS UPDRS, Part IV Physician evaluation Patient diary Physician questionnaire UPDRS, dyskinesia scale Physician evaluation Physician evaluation.
References: 1. Fisher B, Johnston D, Leake P. June 2002 ; . Marijuana for medicinal purposes: an evidence based assessment. A research project sponsored by Medical Services. Workers' Compensation Board Alberta. Downloaded from : worksafebc health care providers Assets PDF marijuana m edicinal purposes in May 30, 2006. 2 Sativex Complete Drug Monograph. Downloaded from : ecps.pharmacists CPHA main in June 12, 2006. 3 Marinol. Complete Drug Monograph. Downloaded from : ecps.pharmacists CPHA main in June 12, 2006. 4 Cesamet Complete Drug Monograph. Downloaded from : ecps.pharmacists CPHA main in June 12, 2006. 5. Campbell FA, Tramer MR, Carroll D et al. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. BMJ. 2001; 323 7303 ; : 13-16. 6 Technote. Use of cannabis or cannabinoids for non-malignant chronic pain February 2004 ; . Alberta Heritage Foundation for Medical Research. Health Technology Assessment. Downloaded from : ahfmr.ab download 6d3b1f36e8bad158824ab55612fa6b5a . in March 2004. 7. Berlach DM, Shir Y, Ware MA. Experience with the synthetic cannabinoid nabilone in chronic noncancer pain. Pain Medicine. 2006; 7 1 ; : 25-29. 8. Berman JS, Symonds C, Birch R. Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of randomized controlled trial. Pain. Dec 2004; 112 3 ; : 299-306. 9. Iversen L. Long term effects of exposure to cannabis. Current Opinion in Pharmacology. 2005; 5 1 ; : 69-72. 10. Karst M, Salim K, Burstein S et al. Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain. A randomized controlled trial. JAMA. Oct 2003; 290 13 ; : 1757-1762. 11. Notcutt W, Price M, Miller R et al. Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 `N of studies. Anaesthesia. May 2004; 59 5 ; : 440-452. 12. Rog DJ, Nurmikko TJ, Friede T and Young CA. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology. 2005; 65 6 ; : 812-819. 13. Berman J, Lee J, Cooper M et al. Efficacy of two cannabis-based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of randomized controlled trial. Anaesthesia. 2003; 58 9 ; : 938. 14. Wade DT, Robson P, House H et al. A preliminary controlled study to determine whether whole plant cannabis extracts can improve instractable neurogenic symptoms. Clinical Rehabilitation. 2003; 17 1 ; : 21-29. 15. Zajicek J, Fox K. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis CAMS study ; : multicentre randomized placebo controlled trial. Lancet 2003; 362 9395 ; : 1517-1526.
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Nents. In this study, we have demonstrated that formation of an HA versican pericellular matrix promoted prostate cancer motility in Boyden chamber motility assays using fibronectin as a chemoattractant. In addition we demonstrated polar pericellular sheath formation particularly at the trailing edge of motile PC3 cells in wound migration assays, while there was no evidence of pericellular sheath at the leading edge of cells. We propose that tumor cells form a polarized pericellular sheath through compartmentalized cell surface CD44 expression and subsequent assembly of HA versican aggregates. The absence of a pericellular sheath at the leading edge of the cell may allow attraction and binding to ECM components such as fibronectin while formation of a pericellular sheath at the trailing edge of cells inhibits cellular binding to ECM components. The combination of binding at the leading edge of cells and inhibition of binding at the trailing edge may enhance the forward motion of the cells. This notion is supported by the demonstration in this study of polarized pericellular sheath formation in motile prostate cancer cells. The description of abundant versican in the trailing tracks of migrating fibroblasts 42 ; and pericellular sheath at the trailing edge of migrating smooth muscle cells 11 ; also supports this model. In summary, we have demonstrated that prostate cancer cells in vitro have the ability to recruit ECM components produced by prostatic stromal cells to promote their motility. These findings are consistent with a scenario whereby the formation of a pericellular sheath in vivo by prostate cancer cells utilizing versican and HA laid down by prostate stromal cells may contribute to the development of metastatic disease.
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McTighe, K., "Socrates on Desire for the Good and the Involuntariness of Wrongdoing: Gorgias 466a-468e", Phronesis 29 1984 ; McTighe 1984 ; . Meattini, V., Anamnesi e conoscenza in Platone, Pisa 1981 Meattini 1981 ; . Migliori, M, "Tra polifonia e puzzle. Esempi di rilettura del `gioco' filosofico di Platone", in La struttura del dialogo platonico, a cura di Gianni Casertano, Napoli 2000, 171-212 Migliori 2000 ; . Migliori, M, "Comment Platon crit-il ? Exemples d'une criture caractre `protreptique'", in La philosophie de Platon, Tome 2, sous la direction de M. Fattal, Paris 2005 Migliori 2005 ; . Moline, J., "Meno's Paradox?", Phronesis 14 1969 ; Moline 1969 ; . Moline, J., "Plato on the complexity of the psyche", Archiv fr Geschichte der Philosophie 60 1 1978 ; 1-26 Moline 1978 ; . Monoson, S., Plato's Democratic Entanglements, Princeton 2000 Monoson 2000 ; . Montuori, M., "John Burnet e la socratica cura dell'anima", Quaderni di Storia 43 1996 ; 269-277 Montuori 1996 ; . Moravcsik J., "Learning as Recollection", in G. Vlastos ed. ; , Plato: a Collection of critical Essays. I: Metaphysics and Epistemology, New York 1971, 53-69; reprint and in Day ed. ; , Plato's Meno in Focus 1994, 112-128 Moravcsik 1971, 1994 ; . Morgan, K., Myth and Philosophy from the Presocratics to Plato, Cambridge 2003 Morgan 2003 ; . Morrow, G. R., "Plato's Concept of Persuasion", Philosophical Review 62 1953 ; 234-250 Morrow 1953 ; . Most, G. W., "Platons exoterische Mythen", in M. Janka & C. Schfer edd. ; , Platons als Mythologe, Neue Interpretationen zu den Mythen in Platons Dialogen, Darmstadt 2002, 7-19 Most 2002 ; . Mueller, I., "Mathematical Method and philosophical Truth", in R. Kraut ed. ; , The Cambridge Companion to Plato, Cambridge 1992, 170-95 Mueller 1992 ; . Mugler, Ch., Platon et la recherche mathmatique de son poque, Strasbourg-Zurich 1948 Mugler 1948 ; . Mugler, Ch., Dictionnaire Historique de la terminologie gomtrique des grecs, Paris 1958 Mugler 1958 ; . Murray, P., "What is a Muthos for Plato?", in Richard Buxton ed. ; , From Myth to Reason? Studies in the Development of Greek Thought, Oxford 1999 Murray 1999 ; . Nacht, S., "Un passo del Menone di Platone 80d-81 ; ", Maia 1 1948 ; Nacht 1948 ; . Naddaff, R. A., Exiling the Poets, Chicago-London 2002 Naddaff 2002 ; . Nails, D., The People of Plato. A Prosopography of Plato and Other Socratics, Indianopolis Cambridge 2002 Nails 2002 ; . Nakhnikian G. "The First Socratic Paradox, " [originally published in Journal of the History of Philosophy 11 1973 ; , 1-17]; repr. in J. N. Day, ed. ; , Plato's Meno in Focus, introd., transl., and articles, London New York 1994, 129-151 Nakhnikian 1973, 1994 ; . Napolitano Valditara, L. M., Lo sguardo nel buio. Metafore visive e forme greco-antiche della razionalit, Roma Bari 1994 Napolitano 1994 ; . Napolitano Valditara, L. M., Prospettive' del gioire e del soffrire nell'etica di Platone, Trieste 2001 Napolitano 2001.
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